Covid vaccine: Pregnant women should be offered jab - but Pfizer and Moderna ‘preferable’ to AstraZeneca

Data from the US has shown women who received Covid jabs did so “without any safety concerns”

Pregnant women should be offered a Covid-19 vaccination at the same time as the rest of the UK population, based on their age and clinical risk group, new guidance recommends.

The Joint Committee on Vaccination and Immunisation (JCVI) has said there were “no specific safety concerns” identified with any brand of coronavirus vaccines available in relation to pregnancy.

Pfizer and Moderna ‘preferable’

The JCVI is advising it is “preferable” for pregnant women to get the Pfizer or Moderna jabs (Photo: Getty Images / Shutterstock)The JCVI is advising it is “preferable” for pregnant women to get the Pfizer or Moderna jabs (Photo: Getty Images / Shutterstock)
The JCVI is advising it is “preferable” for pregnant women to get the Pfizer or Moderna jabs (Photo: Getty Images / Shutterstock)

Under previous guidance, Covid-19 vaccinations have only been offered to pregnant women when their risk of exposure to the virus was high, such as health workers, or if a woman had underlying conditions placing her at higher risk of coronavirus-related complications.

Data from the US showed around 90,000 pregnant women had received coronavirus jabs, which were mainly the Pfizer and Moderna vaccines, “without any safety concerns being raised”.

As a result, the JCVI is now advising that it is “preferable” for pregnant women in the UK to be offered these two vaccines where available.

It said: “There is no evidence to suggest that other vaccines are unsafe for pregnant women, but more research is needed.”

It is understood that the Pfizer and Moderna vaccines are considered preferable because they are the jabs for which safety information relating to pregnant women is available, whereas there currently is not as much relevant data on other vaccines, such AstraZeneca.

Professor Wei Shen Lim, Covid-19 chair for JCVI, said: “We encourage pregnant women to discuss the risks and benefits with their clinician – those at increased risk of severe outcomes from Covid-19 are encouraged to promptly take up the offer of vaccination when offered.

“There have been no specific safety concerns from any brand of Covid-19 vaccines in relation to pregnancy.

“There are more real-world safety data from the US in relation to the Pfizer-BioNTech and Moderna vaccines in women who are pregnant – therefore, we advise a preference for these to be offered to pregnant women.”

Dr Mary Ramsay, head of immunisation at Public Health England (PHE), added: “The available data on the Pfizer-BioNTech and Moderna vaccines provide confidence that they can be offered safely to pregnant women.

“The Covid-19 vaccines continue to save thousands of lives and it is important that we encourage as many people as possible to take up the offer when it is their turn.”

Discuss the risks

The JCVI is still advising pregnant women to discuss the risks and benefits of being vaccinated against Covid-19 with their clinician beforehand

It added that, although uncommon, severe illness due to Covid-19 is more likely in later pregnancy.

Pregnant women with symptomatic Covid-19 infection are two to three times more likely to give birth prematurely, according to the JCVI.

It explained that the “greatest risk factor” for severe Covid-19 outcomes is age, “which is why pregnant women should be invited for vaccination along with their age or clinical risk group”.

The new advice was welcomed by the Royal College of Obstetricians and Gynaecologists (RCOG) and the Royal College of Midwives (RCM).

Professor Lucy Chappell, consultant obstetrician and Covid-19 vaccine lead for the RCOG, said: “This announcement from the JCVI brings the UK into line with the US and other countries who have been offering the Covid-19 vaccine to pregnant women since December, and should provide reassurance to pregnant women, as well as those planning a pregnancy or breastfeeding, that vaccination is an option for them.

“We are continuing to work with healthcare professionals so they are able to counsel pregnant women on the risks and benefits of having the Covid-19 vaccine based on their individual circumstances.”

She added that the RCOG was also advocating for more data collection on pregnant women receiving vaccines in the UK.

Dr Mary Ross-Davie, director for professional midwifery and Covid-19 vaccine lead at the RCM, said the advice “empowers pregnant women to make their own decisions about whether or not to receive the vaccine”.

“Ultimately it will be a woman’s choice and midwives and obstetricians will be there to support them to make an informed decision that is right for them.

“It is now vital that the national vaccination programme, GPs and maternity services are supported to develop systems and procedures that support women who wish to have the vaccine to have it as easily as possible.”

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