The rivals go head to head for the first time in the Premier League at Elland Road in more than 17 years.
Man United came out on top in the first encounter this season, running out 6-2 winners at Old Trafford as they cut open Marcelo Bielsa’s side at will.
Leeds gained admirers for their non-stop running and workrate in that game, however, even when they were 4-0 down, and Saha says Ole Gunnar Solskjaer’s men must expect another ‘fast’ game.
The Frenchman said: “I think going to Leeds is going to be a tough game physically. Mentally you need to be very focused because you are challenged physically.
"It’s the team who are able to express themselves in those kinds of circumstances who can win. So I think it’s going to be a tough game and an entertaining game.
"Leeds play a fast game and lots of high pressing and lots of good players. They don’t have the big name players, but they are very smart and very composed so it will be a good game.”
The Red Devils sit second in the Premier League table, and are in the semi-final of the Europa League as they look to finish the campaign strongly and pick up some silverware.
Solksjaer’s team are in good form, with just one defeat in their last 20 games in all competitions – an FA Cup quarter-final reverse against Leicester City.
Saha says that their ‘better players’ will see them come out on top against Leeds.
“I think they [Man United] are still favourites and playing well,” he told GentingBet. “They have that kind of fire that expresses confidence as well.
"Even if they go down, like they went 1-0 down against Tottenham and won 3-1, you see them being unfairly behind but still not panicking and remaining in control.
"They manage to express the talent at some point in the game and physically that’s what they need to do. Even if they have moments where Leeds dominate, because they will in some patches of the game, United will still come out stronger because they have the better players.”
One player Saha would like to see Solksjaer add to his squad, though, is Erling Haaland. The Borussia Dortmund striker was born in Yorkshire, and is the son of ex-Leeds midfielder Alfie Inge Haaland.
Saha believes the signing of the 20-year-old, or England captain Harry Kane, would move Man United on to the next level.
He added: “I think when you look at Harry Kane and Haaland, it’s two different profiles but they score goals.
"Haaland has a great future, he is a top striker and you can see he already has that fire in him so he will really help any side in this world because of that. He’s got the size, he’s got the speed, he’s got all the qualities you need to be a top striker.
"Harry is more about consistency, you know what he’s going to give you. He’s like a super striker, but a super team player as well. A captain in so many ways.
"If they want to win a Championship these are the kind of players you have to get. The one player with 30 games and 30 goals, it’s scary. When you have one of these kind of players with the youth we have in the side, my god, it’s scary.”