The Gunners and the Reds are both struggling in the race to secure European football for next season, but a win here for either side could spark a push up the table as the 2020/21 campaign heads into its final handful of matches.
Writing his weekly predictions column for BBC Sport, pundit and broadcaster Mark Lawrenson gave his scoreline verdict ahead of the game, and backed his former club to claim a narrow 2-1 win at the Emirates Stadium.
Lawro contended: "This is a big game for Liverpool and their top-four hopes, at the start of a big week for the Reds - they have the first leg of their Champions League quarter-final against Real Madrid on Tuesday.
“It is hard to know what sort of test they will get from Arsenal, though, because we saw how good, and bad, the Gunners can be in their 3-3 draw with West Ham last time out.
“I am not sure how Arsenal boss Mikel Arteta has got any hair left after watching that - he must have been tearing it out at times.
“Liverpool cannot really afford to rest anyone here, even though Jurgen Klopp would probably like to. They need a win to stay close to Chelsea, who are in fourth place, and I think they will get it.”
Meanwhile, celebrity guest opponent for the week, singer-songwriter David Gray, went for a 2-2 draw.