The Blades look set to go back down to the Championship next season, but they'll be hopeful of replicating Norwich City's immediate bounce back up to the top tier, if they're able to hang on to some key players and hit the ground running when the 2021/22 campaign gets underway in August.
A wide variety of managerial candidates have been linked with the job over the past few weeks, including the like of ex-Celtic boss Neil Lennon, former Bournemouth coach Eddie Howe, and current interim manager Paul Heckingbottom, whose last full-time management gig was with Hibernian.
Here's our rundown of OddsChecker's latest predictions on who will become the next Sheffield United manager, ranked from lowest to highest chance of getting the job:
1. Roy Keane
Current odds: 25/1. Current job: Unemployed. Career win percentage: 38.7%. It's been a decade since he last managed, but he's believe to be keen on parking his punditry career and getting back into the dugout.
Photo: NICK POTTS
2. Neil Warnock
Current odds: 20/1. Current job: Middlesbrough. Career win percentage: 40.1%. He's only recently signed a new deal with Boro, and looks unlikely to jump ship back to his former club.
Photo: Jacques Feeney
3. Neil Lennon
Current odds: 20/1. Current job: Unemployed. Career win percentage: 58%. After getting the boot from Celtic, Lennon will be desperate to prove himself again. His odds of getting the Blades job are pretty long, mind.
Photo: Ian MacNicol
4. Mark Hughes
Current odds: 20/1. Current job: Unemployed. Career win percentage: 37.4%. He's not had a manager's job since 2018, but always seems to pop up on the bookies' shortlists.
Photo: Laurence Griffiths