Ukraine currently sit top of the League B - Group 1 table with seven points from their opening three fixtures, while Scotland could overtake them with a win as they sit second with six points.
Ahead of the match, here is everything you need to know about how to watch the action live on TV, online or in person:
What channel is Scotland vs Ukraine UEFA Nations League match on?
Premier Sport will be broadcasting all of Scotland’s UEFA Nations League matches including Wednesday’s meeting with Ukraine at Hampden Park.
Build up starts at 7pm (BST) on Premier 1 (Sky Channel 412, Virgin Channel 551) ahead of a 7:45pm kick off.
ITV will be showing the Ukraine match for free via ITV4 (Sky Channel 120, Virgin Channel 178), although they won’t show the following match against the Republic of Ireland. Coverage will begin at 7pm.
BBC One Scotland will show extended highlights of the match on their Sportscene programme at 10:40pm.
Scotland vs Ukraine live stream
Viewers will be able to live stream the game for free via the ITV Hub.
Premier Sports subscribers can access a live stream to the match via the Premier Player app or online at the Premier Sports website.
A one month subscription for Premier Player costs £9.99 and would cover all three of Scotland’s UEFA Nations League matches in September.
There are also package options to access the channels through Sky, Virgin, Amazon Prime and netgem.
Scotland vs Ukraine UEFA Nations League tickets
Tickets for the UEFA Nations League match between Scotland and Ukraine at Hampden Park on Wednesday, September 21 are still available to purchase.
At the time of publication there are limited tickets still available in the East Stand while the majority of remaining briefs are for the South Stand Upper level.
Adult tickets are priced at £25 - £30 while Under 16 tickets are £5 - £15 and Senior tickets are £10 - £15.
To purchase tickets, visit the official Scotland Football Association website.
Scotland UEFA Nations League fixtures and league table
Scotland’s remaining three UEFA Nations League fixtures are:
- Scotland vs Ukraine - Wednesday, September 21
- Scotland vs Republic of Ireland, Saturday, September 24
- Ukraine vs Scotland, Wednesday September 27
Steve Clarke’s side know that seven points from their three matches will guarantee they finish top of the table regardless of results elsewhere.
That would mean promotion to League A of the Nations League and a guaranteed UEFA European Championships play-off qualifier.
Ahead of their first meeting with Ukraine, here is how the table looks:
- Ukraine - Points 7, GD +4
- Scotland - Points 6, GD +2
- Rep. of Ireland - Points 4, GD +1
- Armenia - Points 3, GD -7
Scotland vs Ukraine match odds
The early betting odds for the match at Hampden Park have Scotland as slight favourites at 6/4 but it’s a tight contest with the visitors starting at 2/1 and the draw also 2/1.
Scotland attackers Che Adams, Lyndon Dykes and Ryan Christie along with Ukraine’s Roman Yaremchuk and Andrii Yarmolenko are the joint 5/1 favourites to score the first goal.
*All odds correct at time of publication.