It will be the first home match of the tournament for Eddie Jones’ side who are looking to build on their 33-0 demolition job in Rome while Wales are riding a wave of confidence following a 20-17 victory against Scotland in Round Two.
It’s the second of the third round fixtures which begin with an intriguing clash between tournament favourites France and Gregor Townsend’s Scotland at Murrayfield before Ireland and Italy finish off the weekend in Dublin.
Here is everything you need to know about how to watch the match, when and where it kicks off and how the teams will line-up:
England v Wales Six Nations 2022 date and kick off time
England v Wales is the second match in Round Three of the 2022 Six Nations and kicks off at 16:45 UK time on Saturday, February 26.
Twickenham Stadium in London, which hosts all of England’s home rugby internationals, will be the venue for the fixture.
Wales hammered England 40-24 in last year’s championship at the Princiaplity Stadium but their last visit to the ‘Home of Rugby’ saw them narrowly beaten as the hosts won 33-30 in 2020.
England v Wales Six Nations 2022 team news
Both teams have already been named ahead of the match.
England make five changes to the side that beat Italy in Round Two with Courtney Lawes returning from injury and taking over the captaincy from fellow flanker Tom Curry.
Manu Tuilagi also makes his first appearance of the the tournament.
Starting XV: Ellis Genge, Luke Cowan-Dickie, Kyle Sinckler, Charlie Ewels, Maro Itoje, Courtney Lawes (C), Tom Curry, Alex Dombrandt, Harry Randall, Marcus Smith, Jack Nowell, Manu Tuilagi, Henry Slade, Max Malins, Freddie Steward.
Replacements: Jamie George, Joe Marler, Will Stuart, Nick Isiekwe, Sam Simmonds, Ben Youngs, George Ford, Elliot Daly.
Wales make just two changes to the side that beat Scotland and Taulupe Faletau is a welcome return from injury to start at Number 8 alongside Ross Moriarty and Taine Basham in the back row.
The other change sees winger Louis Rees-Zammit drop out of the squad completely and Josh Adams replace him.
Starting XV: Wyn Jones, Ryan Elias, Thomas Francis, Will Rowlands, Adam Beard, Ross Moriarty, Taine Basham, Talupe Faletau, Tomos Williams, Dan Biggar (C), Josh Adams, Nick Tompkins, Alex Cuthbert, Liam Williams.
Replacements: Dewi Lake, Gareth Thomas, Leon Brown, Seb Davies, Jac Morgan, Kieran Hardy, Gareth Anscombe, Jonathan Davies.
What channel is England v Wales on? How to watch Six Nations 2022 and live stream
UK Viewers can watch the game live on ITV from 16:00 which is 45 minutes before the match kicks off.
The match will also be streamed live on the ITV Player.
ITV have the rights to broadcast all of England’s home matches at the 2022 Six Nations.
England v Wales Six Nations 2022 - latest match odds
England are heavy favourites to win the match and start at 6/1 while Wales are 4/1 outsiders.
First try scorer betting include Max Malin at 8/1 and Alex Cuthbert at 14/1.
Both teams are still technically able to win the Six Nations Championship this year with England currently third favourite behind France and Ireland at 5/1 while Wales are bug outsiders at 50/1.
*All odds correct at the time of publication.
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