Like last season, substitutions could be crucial for each side in the Champions League as they look to avoid any serious injuries and fatigue with the competition forming an integral part of the business end of the campaign.
This has been particularly potent for Liverpool who had been aiming to achieve the miraculous quarduple: the Carabao Cup, FA Cup, Champions League and Premier League title.
Liverpool have successfully lifted the Carabao Cup and FA Cup but were denied the chance to lift the Premier League after a dramatic final Sunday saw Manchester City take the league title for the sixth time in their history.
City came from 2-0 down at half-time to beat Aston Villa 3-2 within the final 10 minutes of the match to ensure that Liverpool were unable to lift all four trophies.
The Reds 3-1 win over Wolves was not enough to pull themselves above their Mancunian rivals but will look to console themselves as they prepare for the UEFA Champions League this weekend...
How many substitutions can teams make in the Champions League this season?
As a result of the pandemic last season, teams were allowed to make six substituions during Champions League matches and the rules for the 2021/22 campaign are similar.
Teams during the group stages are allowed to make five changes per game. However, if they make it through to the knockouts, they can make five inside 90 minutes and then an extra sixth sub if the tie goes to extra-time.
To look at the rules in more detail, the Uefa rulebook states: "Each team may use a maximum of three stoppages in play to make substitutions (one additional stoppage in extra-time can be used).
"Substitutions made before the start of the match, during half-time, between the end of normal playing time and extra time, and at half-time during extra time do not reduce the number of stoppages in play that can be used.”
When is the UEFA Champions League final?
The final is scheduled to take place on Saturday 28 May 2022. Kick off is set for 8pm BST and the final will take place at the Stade de France, Paris.
The final had been due to take place in St Petersbourg but was relocated after Russia’s invasion of Ukraine.
Liverpool and Real Madrid have met a total of eight times in competitive matches with Real winning on four occasions and Liverpool winning on three.
How to watch UEFA Champions League?
Liverpool and Real Madrid will be available to watch on BT Sport. Coverage of the match will start at 7pm BST with subscriptions costing around £25/month.