That may be very unlikely, but Spurs can boost their own chase for the top four positions in the league and also seriously dent the ambitions of one of the main players in that race this weekend.
For Manchester United, given that Arsenal will have four games in hand by the end of the day, it is inconceivable for Ralf Rangnick's side that they lose this game to a close rival, and coming off the capitulation in the Manchester Derby.
It is surely a must-win for the hosts in the 5.30pm match that sees two of the biggest clubs in English football collide, with both playing out disappointing league campaigns so far.
This big clash between top four hopefuls precedes the second leg of United's Champions League tie with Atletico Madrid, which Rangnick and co may have half an eye on too.
Spurs will go above the Red Devils in the league if they take the three points, while a draw likely doesn't help either side.
Spurs are looking for a third win in four visits to the Theatre of Dreams and they head north off the back of inconsistent form: three wins and three losses in their last six games.
Antonio Conte's side thrashed Everton 5-0 on Monday evening and have won four of their last six games on the road.
Manchester United have won two of their last six Premier League matches, and three of their last six home games.
How to watch
The match is available to watch on Sky Sports' Main Event and HD2 channels from 5pm. Kick off is 5.30pm.
You can watch the match abroad from licensed broadcasters, such as CBS in the US.
Where are they playing?
The match will be played at Old Trafford in Manchester.
United will welcome back Cristiano Ronaldo after a hip injury ruled the Portuguese superstar out of the defeat at the Etihad last weekend. Edinson Cavani is likely to be fit too, while Luke Shaw and Raphael Varane should return after positive Covid tests the week before.
Tottenham will be without Ryan Sessegnon (hamstring), Oliver Skipp (groin) and Japhet Tanganga (knee). The rest of the Spurs squad is expected to be available.
Manchester United probable line-up:
Gea; Dalot, Varane, Maguire, Shaw; Fred, McTominay; Pogba, Fernandes; Ronaldo, Sancho.
Tottenham Hotspur probable line-up:
Lloris; Romero, Dier, Davies; Doherty, Bentancur, Hojbjerg, Reguilon; Kulusevski, Kane, Son.